Det finnes lite dokumentasjon for effekt av kodein, tramadol, dekstropropoksyfen og pentazocin mot kroniske smerter. Statens legemiddelverk anbefaler samme retningslinjer for alle opioide analgetika ved behandling av langvarige smerter (six): Pasienten skal informeres grundig om virkninger og bivirk
Ved smertebehandling er det nyttig å skjelne mellom akutt smerte, smerte less than vevstilhelingsprosesser og langvarig eller kronisk smerte som vedvarer uforklarlig etter at vevet synes tilhelet.
Uansett hvilke legemidler som ble brukt, har guy sett at behandling av langvarige smerter med
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